Arm infection

An 85 year old man was diagnosed with polymyalgia rheumatica and treated with high dose prednisone. While on approximately 50 mg of prednisone these lesions started to appear. Despite tapering of prednisone the lesions progressed.

This photograph was taken about 3 months after first appearance. He was not systemically unwell, had not travelled outside of Canada and had no unusual contacts with animals.

Stains of material taken from lesions showed abundant Acid-Fast Bacilli and cultures were positive in two days. The organism was identified as Mycobacterium abscessus – one of a group of “atypical” mycobacteria referred to as Rapid Growers.

These organisms are found in the environment and rarely cause infections. When they do, however, they are difficult to treat as they are inherently resistant to many antibiotics. M. abscessus in particular has gained notoriety in recent times as a cause of healthcare-associated infections often involving contaminated medical devices. See CDC Mycobacterium abscessus in Healthcare Settings. Johns-Hopkins has a useful guide to therapy in their POC-IT guide series that can be viewed here Johns-Hopkins M. abscessus.

Cystitis in Adult Females

Uncomplicated Cystitis

Recommended Empiric Therapy

Nitrofurantoin (MACROBID) 100 mg PO BID for 5 days

  • Avoid near term pregnancy: greater than 35 weeks
  • Avoid if GFR less than 60 ml/min

OR

TMP/SMX 1 DS tab PO BID for 3 days

  • Avoid in 1st trimester and last 6 weeks of pregnancy

OR

Cefixime 400 mg PO daily for 3 days

Complicated cystitis

  • Age greater than 55 years
  • Symptoms lasting greater than 7 days
  • Diabetes Mellitus
  • Structural abnormality of urinary tract
  • Spinal cord injury
  • Multiple sclerosis
  • Pregnancy

Tailor therapy once C&S results obtained and treat for a total of 7 days. 

Recommended Empiric Therapy

Amoxicillin clavulanate 500 mg PO TID

OR

TMP/SMX 1 DS tab PO BID

  • Avoid in 1st trimester and last 6 weeks of pregnancy

OR

Cefixime 400 mg PO daily

Stewardship is Structure

Certainly in the Canadian context, Antimicrobial Stewardship is a public service.

public service noun

  1. : the business of supplying a commodity (as electricity or gas) or service (as transportation) to any or all members of a community
  2. : a service rendered in the public interest

It fulfills both of these dictionary definitions perfectly. Stewardship programs provide a service to members of communities — The community of healthcare providers to aid in their provision of care and to the community at large to provide the ongoing benefits of the availability of effective antimicrobials. This is very much in the public interest.

More established public services such as the police, fire fighting and waste removal are easy to conceptualize and understand. Others such as fisheries and forest management are more difficult. Few would dispute that the management of common resources is important, however. Common to all are several elements.

Information
Could the Department of Fisheries perform its’ functions without information? Of course not. Just as information about fish stocks is necessary to define sustainable fish harvest quotas, information is necessary to manage antibiotics. Fortunately, much of the information needed to manage antibiotic use is readily available. Millions of susceptibility tests are performed and all antibiotics distributed for human use are under prescription and have records associated. We haven’t yet done a good job of collation, redistribution and display but it is only a small amount of idea and resource away.

Manpower
Nothing ever prospers as a “side of the desk” endeavour. Why would Antimicrobial Stewardship be any different? It needs dedicated thoughtful people with appropriate skill sets – just like anything else. The good news is that evaluations of established AS programs have shown cost savings even after taking account the increased expenditures on manpower. Antimicrobials have been so poorly managed that there is much wasted resource. There is a large potential to turn misused antimicrobials into excellent, well-paid, stable jobs for Canadians.

Policies and Procedures
Policies are informed by principles and guide procedures. Goal statements and metrics for evaluation are central. Nothing unusual about this. However, this is new in Canada and much trial and error is to be expected. The principles should be firmly established but procedures will necessarily be diverse as Canadian health delivery is diverse.

Education
The cornerstone of sustainability. All established conservation programs become easier to enact as the benefits are recognized by more and more people. They become the norm.

Canada is poised for a Antimicrobial Stewardship revolution. We have the enthusiasm, the people and the need. We just need some structure.

Personal Protective Equipment

Personal protective equipment (PPE) is used for two reasons:

  • To protect staff from blood or body fluid contamination
  • To reduce the risk of cross infection through the reduction in contamination and transferring of microorganisms to other patients/residents, staff, visitors and the environment

Gloves

The hands of clinical staff are the most likely means of transmission of healthcare associated infection. Through hand washing and the appropriate use of gloves the risk of cross infection is minimized.

There are a number of materials used in the manufacture of gloves, including latex, nitrile and vinyl (PVC). The choice of material will depend on the type of task being performed, contact with chemicals and the risks associated with latex sensitization.

The use of vinyl gloves is not recommended for prolonged tasks that require manual dexterity or when contact with blood or body fluids is anticipated.

The purpose of wearing gloves is to either prevent the hands becoming contaminated with dirt or microorganisms, or to prevent the transfer of organisms already present on the skin or the hands. It is essential to ensure that hands are washed before putting on gloves and following the removal of gloves.

Selection of glove type

Most tasks require non-sterile gloves. These are made of latex or nitrile (for latex allergic users) and come in boxes with many gloves in each box in small, medium and large sizes.

Sterile gloves are worn to protect the patient during aseptic invasive procedures such as in the operating room. These gloves come in individually wrapped pairs in various numeric sizes.

Storage of disposable gloves

It is important to store latex and nitrile gloves separately at all times to avoid getting latex onto the nitrile gloves. This will include, and not be exclusive to, the clean utility room and within all clinical area where the gloves are available for use.

Gloves must be worn:

  • When touching mucous membrane
  • When changing a dressing, or having contact with non-intact skin
  • When changing diapers or adult briefs
  • When performing personal hygiene for clients
  • When performing mouth care
  • When indicated for Additional Precautions

Gloves should not be worn:

  • When there is no risk of exposure/ splash/ contact with blood, body fluids and non-intact skin
  • When assisting or feeding a patient
  • For social touch
  • When pushing a wheelchair
  • When delivering meals, mail, clean linen
  • For providing care to clients with intact skin, e.g. taking temperature

Patient Placement

A further aspect of routine practices is the decision making process for patient placement. Options include single patient rooms, two patient rooms and multi-bedded rooms/bays.

Single room accommodation is always the preferred option. However, most facilities have limited resources in this area, and competing considerations when determining the appropriate placement of patients/residents.

Single patient rooms are always preferred when there is a concern about the transmission of an infectious agent. In situations that require prioritization of such accommodation, it is prudent to prioritize these rooms for patients/residents who pose a high cross infection risk to other patients/residents, particularly for those who are at increased risk of an adverse outcome from the acquisition of an infection.

Occasionally, due to the number of patients/residents who are colonized or infected with the same organism, cohorting the group of patients/residents in the same area may be an option (see ARO Room Placement).

Respiratory Hygiene/Cough Etiquette

The outbreaks of SARS in 2003 and recent swine flu pandemic have highlighted the need for vigilance and prompt implementation of infection prevention and control measures at the first point of encounter within a healthcare setting.

This UK Department of Health TV ad promoting good respiratory hygiene graphically highlighted the issue during the swine flu pandemic.

Catch it, Bin it, Kill it from Jim Hutchinson on Vimeo.

Respiratory hygiene/cough etiquette is targeted at patients/residents and accompanying family members and friends with undiagnosed transmissible respiratory infections, and applies to any person with signs of illness, including cough, congestion, rhinorrhea (runny nose) or increased production of respiratory secretions when entering a healthcare facility.

The elements of respiratory hygiene/cough etiquette include:

  • Education of healthcare facility staff, patients/residents and visitors
  • Posted signs, in languages appropriate to the population being served, with instructions to patients/residents and visitors
  • Source control measures (e.g. covering the mouth and nose with a tissue when coughing and prompt disposal of used tissues, using surgical masks on the coughing person when tolerated and appropriate)
  • Hand hygiene after contact with respiratory secretions
  • Spatial separation, ideally more than 6 feet between persons with respiratory infection in common areas, when possible

It should be noted that although fever will be present in many respiratory infections, patients/residents who are very old or very young and patients/residents with pertussis and mild upper respiratory tract infections are often afebrile. Therefore, the absence of fever does not always exclude serious respiratory infections.

Patients/residents who have asthma, allergic rhinitis or chronic obstructive lung disease also may be coughing and sneezing. While these patients/residents often are not infectious, cough etiquette measures are prudent.

Healthcare personnel are advised to observe droplet precautions and hand hygiene when examining and caring for patients/residents with signs and symptoms of respiratory infection.

Healthcare personnel who have a respiratory infection are advised to avoid direct patient contact, especially with high risk patients/residents. If this is not possible, then a mask should be worn while providing patient care.

Modified from: Siegel, J.D., Rhinehart, E., Jackson, M. Chiarello, L. and the Healthcare Infection Control Practices Advisory Committee (2007) Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings. June 2007

Hand Hygiene

Hand hygiene is the single most important procedure for preventing cross infection. Body secretions, excretions, environmental surfaces and hands of all healthcare workers can carry microorganisms (bacteria, viruses and fungi) that are potentially infectious to them and others.

Hand washing is known to reduce patient morbidity and mortality from hospital-acquired infection.


Hand washing technique
Courtesy of the Ontario ministry of health and long-term care.

Indications for Hand Hygiene

The decsion to decontaminate hands should be based on an assessment of the risk that microorganisms have been acquired on the hands and transiently carried to another person or location.

Hand hygiene must be carried out in the following situations:

  • At the beginning of every shift Before contact with any patient
  • In between contact with each and every patient
  • After contact with a patient on Additional Precautions or one who is colonized with microorganisms of special clinical significance, e.g. resistant to a number of antibiotics
  • Before performing mouth care
  • Before and after contact with susceptible sites, e.g. wounds, burns, IV sites
  • Before performing invasive procedures, e.g. where natural defences against infection are breached
  • After hands have been contaminated, e.g. contact with body fluids, soiled linen, equipment or garbage
  • After gloves have been removed
  • Before handling food or medicines
  • Before handling clean linen After using the toilet or after toileting others
  • Before and after eating
  • Prior to entering and leaving a nursing station
  • Prior to using computers and other electronic devices

Hand hygiene may also be desirable at other times. The Infection Prevention and Control Team may request additional requirements for hand hygiene, e.g. during an outbreak of infection.

Nail and Skin Care

The nails are the area of greatest contamination. Short nails are easier to clean and are less likely to tear gloves. Please refer to VIHA‘s Policy 15.1 – Hand Hygiene Policy.

Nail varnish (polish) is prohibited, regardless of colour, for staff with direct patient contact, or who work in areas where direct patient contact takes place

Nail extensions/nail art and acrylic nails are prohibited for staff with direct patient contact, or who work in areas where direct patient contact takes place

Ensure the skin on your hands does not become dry or damaged. In these conditions the hands show a higher bacterial load, which is more difficult to remove than with healthy, intact skin.

Hand lotion may be used to prevent skin damage from frequent hand washing.

Skin lotions for patient and/or staff use have been reported sources of outbreaks, so pump dispensers are preferable over tubes or jars. If a pump dispenser is not available, individualized containers must be used.

Compatibility between lotions and antiseptic products, and lotion’s potential effect on glove integrity should be checked (i.e. lotions should not be petroleum based). Please check with Infection Prevention and Control or Occupational Health and Safety to ensure lotion is approved for use.

Creams that have been taken into a patient’s room should be dedicated to that patient and either disposed of or sent home with the patient on discharge.

Type of Cleansing Agents

Alcohol Based Hand Rub

Use routinely when hands are not physically soiled.

Alcohol based hand rubs (ABHR) can be used in place of soap and water, except where hands are visibly soiled (e.g. feces, blood, etc.). They are especially useful in situations where hand washing and drying facilities are inadequate or where there is a frequent need for hands to be decontaminated (such as in client‘s homes). Every effort should be made to install these products as close to point of care as possible.

Alcohol based surgical scrubs are used in situations where a reduction in the resident microbial flora is considered desirable, such as in an operating theatre or similar department, and before performing an invasive procedure, especially the placement of an indwelling medical device.

The optimal concentration of ABHR is 70-90% with added emollients; a minimum of 70% ethanol will protect against Norovirus. If the ABHR is a gel, a minimum of 80% ethanol is recommended. ABHR dispensers should read volume per volume, not weight per volume.

Reference: WHO, World alliance for Patient Safety (2006) WHO guidelines on hand hygiene in healthcare (advanced draft). April 2006. Report No: WHO/WPI/QPS/05.2

Soap and Water

Indications:

  • When hands are physically soiled
  • When hands look or feel dirty
  • Following contact with blood or body fluids
  • Following contact with any patient with diarrhea/vomiting, and their environment, including bathroom facilities

In clinical areas, soap is supplied as liquid or foam, in sealed containers, where the dispensing nozzle is integral to the container, and changed when the unit is empty. Soap dispenser pumps are never to be reused, refilled or ―topped up‖ and must be disposed of once empty.

It is recommended that hands are washed with soap and water if in contact with spores (e.g. Clostridium difficile), because the physical action of washing, rinsing and drying hands has been proven to be more effective than alcohols, chlorhexidine, iodophors and other antiseptic agents.

Handwashing Technique

A brief wash will remove the majority of transient microorganisms, but the technique should aim to cover all surfaces of the hands. Where soap or a surgical scrub has been used, hands should be rinsed under running water and thoroughly dried with a disposable towel. The soap and hand towels should be of a quality acceptable to users, so as not to deter hand washing. The skin should be maintained in good condition to discourage the accumulation of bacteria.

The optimal concentration of ABHR is 70-90% with added emollients; a minimum of 70% ethanol will protect against Norovirus. If the ABHR is a gel, a minimum of 80% ethanol is recommended. ABHR dispensers should read volume per volume, not weight per volume.

Hand hygiene should include the cleaning of arms to the elbow, especially when wearing a sleeveless apron.

Levels of Hand Disinfection

Social
Used routinely. Soap and water or Alcohol-based hand rub are both acceptable.

Hygienic hand disinfection
Used prior to invasive procedures performed on the units.
Soap and Water FOLLOWED by alcohol-based hand rub.

Aseptic (Surgical scrub)
Used prior to surgical procedures in the operating room or similar.
A 2 minute antiseptic wash (i.e. chlorhexidine CHG 4%) and dry on sterile towels or Soap and water hand wash followed by surgical alcohol based hand rub.

Hand Hygiene Procedure

The areas of the hands that are often missed are the wrist creases, thumbs, fingertips, under the fingernails and under jewelry. For this reason, only a plain wedding band with no stones is acceptable (please refer to VIHA‘s Policy 15.1 – Hand Hygiene Policy).

Alcohol based hand rub technique

  • Soap and water hand wash must be performed if hands look or feel dirty
  • Apply an application to fill cupped palm of one hand
  • Rub into all surfaces of hands (finger tips and nails, wrists, palms, backs of hands and between fingers)
  • There must be sufficient wetness on all skin surfaces that it takes 15 or more seconds to dry
  • Rub hands together until rub has evaporated prior to gloving or touching the patient

Soap and Water hand washing technique

  • Wet your hands up to the wrists ensuring all surfaces of the hands are covered by water
  • Apply the cleanser/soap
  • Smooth it evenly all over your hands, including the thumbs and in between fingers, lather well rubbing vigorously. Place fingertips and nails into the lathered palm and rub. Repeat with opposite hand
  • Rinse off every trace of lather under running water, to prevent skin irritation
  • Dry thoroughly, taking special care between the fingers. More than one paper towel may be necessary

Surgical asepsis (scrub) technique with an alcohol based hand rub

  • Use sufficient product to keep hands and forearms wet with the alcohol based surgical scrub (ABSS) throughout the procedure (usually at least a cupped hand filled with ABSS).
  • Apply ABSS to clean, dry hands and nails:
  • Cup hand and hold 1–2 inches from the nozzle

PUMP 1

  • Dispense first full pump into the cupped palm of one hand (fill cupped hand)
  • Dip fingertips of the opposite hand into the ABSS and work in under the nails and wipe the excess solution from the fingertips back onto the palm of the same hand
  • Spread the remaining amount from the palm from wrist to elbow of the opposite arm, covering all surfaces

PUMP 2

  • Place another full pump into the opposite, dry palm and repeat the above procedure with the other hand

PUMP 3

  • Dispense a final full pump into either palm and reapply to all aspects of both hands up to the wrist
  • Proceed to the operating room suite holding hands above elbows After applying ABSS allow hands and forearms to dry thoroughly before donning sterile gloves and gown.

Surgical asepsis technique with a medicated soap

Wash hands and arms up to elbows with a non-medicated soap before entering the Operating Room area or if hands are visibly soiled

Start timing

  • Scrub each side of each finger, between the fingers and the back and front of the hands for 2 minutes
  • Scrub the arms, keeping the hand higher than the arm at all times. This helps to avoid recontamination of the hands by water running from the elbows, and prevents bacteria laden soap and water from contaminating the hands
  • Wash each side of the arm from wrist to elbow for 1 minute
  • Repeat this process on the other hand and arm, keeping the hands above the elbows at all times. If the hand touches anything except the brush at any time, the scrub must be lengthened by 1 minute for the area that has been contaminated
  • Rinse hands and arms by passing them through the water in one direction only; from fingertips to elbow
  • Proceed to the operating room suite, holding hands above elbows

At all times during the scrub procedure, care should be taken not to splash water onto surgical attire

Once in the operating room suite, hands and arms should be dried using a sterile towel before putting on gown and gloves.

Aseptic technique must be maintained at all times

Toe larvae

A 21 year old, otherwise healthy man presented with a problem with his great toe. He had recently lost his nail in an accident while wading in the ocean and had swum in a swimming pool that was likely not well chlorinated.

As you can see from the image (taken and emailed from his physician’s iphone!) there are numerous larvae that were described and “very active”.

BCCDC identified the larva as Phormia regina – the black blow fly.

After soaking his toe in warm water for 20 minutes the larvae easily came off.