Topic: Amikacin trough recommended for once-daily dosing

Home Forums Laboratory Issues Amikacin trough recommended for once-daily dosing

This topic contains 2 replies, has 3 voices, and was last updated by Lyle Powell Lyle Powell 2 years, 6 months ago.

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  • #1453
    Richard Bachand
    Richard Bachand
    Participant

    There appears to be some inconsistencies in our values as to what is the recommended Amikacin Trough when we are using High-dose amikacin (15-20mg/kg) once daily. I believe the goal would be to have no measureable level. If that is less than 1mg/L then I would support that. I don’t know if we have any evidence that less than 3 is more toxic than less than 1.

    #1456
    Jim Hutchinson
    Jim Hutchinson
    Keymaster

    I like <1

    #1485
    Lyle Powell
    Lyle Powell
    Participant

    I think less than one is the ideal target, given that HEDI (high dose extended interval) takes advantage of aminoglycosides’ pk/pd characteristics including the postantibiotic effect.

    But as for needed a trough in HEDI I would lean towards the Hartford method of monitoring and adjusting (level 8-12 hours post) as your trough could be 0 for 6 hours or 2 minutes which I would think would have an impact on efficacy and toxicity.

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