Nitrofurantoin safety in the elderly

Question

One more question about treating acute cystitis. You recommend against nitrofurantoin in patients over 55y and I was wondering what you think of this relatively recent argument against that: http://academiclifeinem.com/must-we-avoid-nitrofurantoin-with-impaired-renal-function/

Answer

The evidence you point to that nitrofurantoin is likely safe and effective at lower GFRs is important. We need to be able to use all the agents we have remaining as effectively as possible. I think it is worth discussing in a forum. See http://infectionnet.org/forums/topic/can-nitrofurantoin-be-safely-used-in-older-patients/

Answered by Jim Hutchinson.

Category: Toxicity

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