Cystitis in adult females

Uncomplicated Cystitis

Recommended Empiric Therapy

Nitrofurantoin (MACROBID) 100 mg PO BID for 5 days

  • Avoid near term pregnancy: greater than 35 weeks
  • Avoid if GFR less than 60 ml/min

OR

TMP/SMX 1 DS tab PO BID for 3 days

  • Avoid in 1st trimester and last 6 weeks of pregnancy

OR

Cefixime 400 mg PO daily for 3 days

Complicated cystitis

  • Age greater than 55 years
  • Symptoms lasting greater than 7 days
  • Diabetes Mellitus
  • Structural abnormality of urinary tract
  • Spinal cord injury
  • Multiple sclerosis
  • Pregnancy

Tailor therapy once C&S results obtained and treat for a total of 7 days. 

Recommended Empiric Therapy

Amoxicillin clavulanate 500 mg PO TID

OR

TMP/SMX 1 DS tab PO BID

  • Avoid in 1st trimester and last 6 weeks of pregnancy

OR

Cefixime 400 mg PO daily

Category: Urinary Tract Infections

Other Therapy Guidelines

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